Abstract

Therapeutic effect of traditional Chinese medicine bath combined with tacrolimus on atopic dermatitis and serum inflammatory mediators

Author(s): Xinguo Xue

Objective: To investigate the effect of traditional Chinese medicated bath combined with tacrolimus on atopic dermatitis (AD) and its effect on serum inflammatory factors of IgE, IL-4 and IL-5.

Methods: A total of 112 patients with AD were selected as the objects and randomly divided into control group and research group, 56 cases in each group. The control group was given tacrolimus ointment as exterior coating, and the study group was given traditional Chinese medicated on the basis of the control group. Eczema area severity index (EASI) score, serum levels of IgE, IL-4, IL-5, dermatological quality of life index (DLQI) scores of these two groups were compared between prior treatment and after 3 weeks treatment. The evaluation of clinical curative effect was given at the end of treatment assessment, drug adverse reactions were compared during the treatment period, understood the recurrence after 3 months follow-up.

Results: The effective rate of treatment in the research group was 89.3%, which was significantly higher than that in the control group of 69.6% (P <0.05). There was no statistical significance of difference in EASI and DLQI scores, serum levels of IgE, IL-4 and IL-5 between the two groups before treatment (P>0.05). After 3 weeks treatment, all of them in research group were significantly lower than those in the control group (P<0.05). The adverse effect rate of cases in research group was 3.6% which was significantly lower than that in the control group of 10.7% (P<0.05). both groups were given 3 months follow up, during that time, 4 cases of recurrence in control group, the recurrence rate was 7.1%, while 5.4% in the research group with 3 cases of recurrence. There was no statistical significance of difference in the recurrence rate between the two groups (P>0.05).

Conclusion: Chinese medicine bath combined with tacrolimus treatment has a good effect of AD, which effectively eliminating the skin lesions, reducing serum levels of IgE, IL-4, IL-5, improving patient-related quality of life, and with a lower adverse effects rate and recurrence rate, it is superior to effect of exterior coating tacrolimus ointment alone.