Short Note on Mechanism-based Enzyme Inactivators of Phytosterol Biosynthesis.

Author(s): Masahiro Onuma

Current progress on the mechanism and substrate recognition by alcohol methyl enzyme (SMT), the role of mechanism-based inactivators, alternative inhibitors of SMT action to probe contact action and phytosterol synthesis is reportable. SMT is a membrane-bound accelerator that catalyzes the coupled C-methylation-deprotonating reaction of alcohol acceptor molecules generating the 24-alkyl alcohol facet chains of fungal steroid alcohol and plant sitosterol.