Abstract
Rheumatoid Factor and Its Role in Rheumatoid Arthritis: A Comprehensive Review
Author(s): Paasikivi V*Rheumatoid factor (RF) is a key autoantibody associated with rheumatoid arthritis (RA), an autoimmune disease that primarily affects the joints. RF targets the Fc region of IgG antibodies, forming immune complexes that contribute to the chronic inflammation and joint damage seen in RA. Although RF is widely used as a diagnostic marker, its clinical significance extends beyond mere detection. This review delves into the role of RF in the pathogenesis, diagnosis, and prognosis of RA. We examine the molecular processes involved in RF production, its influence on immune system activation, and its association with disease severity. Furthermore, we discuss the limitations of RF testing and its role in conjunction with other biomarkers, such as anti-citrullinated protein antibodies (ACPAs), in providing a more comprehensive understanding of RA. A better understanding of RF’s multifactorial role in RA will enhance diagnostic accuracy and facilitate personalized treatment strategies, ultimately improving patient outcomes.