Rare cause of pigmenturia from anti-hydroxy-3-methylglutarylcoenzyme; A reductase (HMGCR) induced muscle necrosis treated with immunosuppression: A Case Report and literature review

Author(s): Ejo John*, Prateek Sanghera & Tim Kelly

Myositis and muscle necrosis can be associated with anti-HMGCR antibody in patients with prior HMG-CoA reductase exposure. There are isolated reports of muscle necrosis in patients with no prior history of statin exposure. We percent a case of severe muscle necrosis with no predisposing factors. Our patient had high anti-HMGCR antibody titers causing rhabdomyolysis, muscle necrosis requiring long-term immunosuppressive agents