Maturation and Migration of Young brain

Author(s): Eila Korhonen

Neuronal migration disorders and other neurodevelopmental disorders are best understood in relation to altered normal development. A wide range of molecular and cellular signaling serves as a guide for neuronal migration from their origin to their (usually cortical) destination. Neurons with abnormal migration include: 1) do not migrate and stay where they came from; 2) migrate in part but stay within the white matter; 3) migrate to the cortex without properly organizing; or (4) migrate excessively beyond the cortex. We discuss normal brain development and the malformations caused by these various migration abnormalities in this review.