Abstract

HLA class I and II alleles may influence susceptibility to adult dermatomyositis in a Mexican mestizo population

Author(s): Gustavo Lugo Zamudio, Rosa Elda Barbosa Cobos, Arelia Solorzano-Ruiz, Elizabeth Lopez Morales and Dolores DelgadoOchoa

Objective: To investigate the possible association between HLA and Dermatomyositis (DM) in the Mexican mestizo population.

Methods: HLA class I (A and B) and class II (DRB1* and DQB1*) were determined in 36 Mexican mestizo patients with DM and 72 healthy controls.

Results: A positive association was identified among alleles HLA A*01:01 (OR 3.5 (1.30-9.54), p<0.012), A* 03:01 (OR 5 (2.11-11.81), p<0.0002), B* 07:02 (OR 3.9 (1.63 - 9.50), p<0.0002), DRB1* 09:01 (OR 5 (2.11- 11.81), p<0.032) and DRB1*01:02 (OR 33.04 (1.86-588.09), p<0.017), and the presence of DM. Protective alleles were identified for the development of disease to DRB1* 16:01 (OR 0.12 (0.015-0.093), p<0.043) and DQB1* 03:02 (OR 0.10 (0.02-0.46), p<0.002).

Conclusions: In this study, identification of alleles related to DM in a Mexican mestizo-population showed the participation of HLA in its development, as reported in other-populations.