Abstract

Histological effects of doxorubicin and baobab plants on some organs of rat

Author(s): Alyaa Ali Al-Safo*, Abeer Mansour Abdel Rasoo, Saif Khalid Yahya

Doxorubicin (DOX) commonly utilized as a chemotherapeutic drug, valuable against numerous different types of cancer, it can cause serious impairment to the liver and kidneys, This impairment is a very dangerous side effect of using this cancer treatment. Doxorubicin induced toxicity is primarily determined by oxidative stress and inflammation. Adansonia digitata. (Baobab) Baobab exhibits numerous biological properties, including antimicrobial, anti-malarial, anti-diarrheal, anti-anemic, antiasthmatic, antiviral, antioxidant, and anti-inflammatory activities, The objective was to determine administering albino rats an aqueous extract of the baobab plant, baobab may reduce the potential histological effects of doxorubicin on the renal and hepatic tissues. Material and method involving forty male albino rats used were divided into four groups the normal control group received 0.5 mL of distilled water, the second group received 15 mg/kg of doxorubicin only, the third group received 15 mg/kg of doxorubicin along with 500 mg/kg of baobab extract, and the fourth group received 500 mg/kg of baobab extract alone the period of current study for 17 day the result showed using baobab enhancement in the renal and hepatic impairment after Doxorubicin administration. The protective effects of using natural product like baobab are likely due to its antioxidant and anti-inflammatory properties, which help restore the normal structure of liver and kidney tissues and prevent damage caused by free radicals produced by doxorubicin.