Highly effective of stabilized silver nanocatalyst of Ibuprofen and Paracetamol drugs for the degradation of heterogeneous doxycycline Activity

Author(s): Ajit Kumar Varma

In the present study was a new doxycycline stabilized silver nanocatalyst (Dox-Ag (0) NPs) was synthesized in aqueous solution (green method) by one-pot simple synthetic method for the ultra-fast catalytic degradation of ibuprofen and paracetamol. The formation of the Dox-Ag (0) NPs was monitored by using UV–Vis absorption spectroscopy which are confirmed the formation of Dox-Ag (0) NPs to exciting the typical surface plasma on absorption maxima at 404 nm. Transmission electron microscopy (TEM) confirmed the spherical morphology and monodispersed Dox-Ag (0) NPs with particle size 6.84 ± 2.2 nm.Doxycycline is a broad-spectrum antibiotic synthetically derived from oxytetracycline The drug is a second-generation tetracycline, exhibiting lesser toxicity than first-generation tetracyclines which are used to treat a wide range of bacterial infections, depending on the results of antibiotic susceptibility testing.Mycoplasma hominis, Escherichia coli, Pseudomonas aeruginosa and Gram-positive bacteria Staphylococcus aureus, Micrococcus flavus and Micrococcus luteus by the disk diffusion method. Whereas standard antibiotic showed no zone of inhibition, the Dox-Ag (0) NPs showed good inhibition zone. The antimicrobial results therefore reveal that newly synthesized Dox-Ag (0) NPs had a tremendous catalytic and antimicrobial activity as a catalyst. They were recovered easily from reaction medium and reused with enhanced catalytic potential seven times. The current findings are equally extendable for safeguarding the aquatic environment against the pollution caused by drugs and microbial activity via a facile, highly economical, rapid and efficient reduction/degradation method based on the catalytic potential of Dox-Ag (0) NPs.