Abstract
Exploring the Genetic Underpinnings of Ankylosing Spondylitis: A Comprehensive Review of Genome-Wide Association Studies
Author(s): Alice Johnson*Ankylosing spondylitis (AS) is a chronic inflammatory disease that primarily affects the axial skeleton, with a strong genetic component. This review examines the findings from recent genome-wide association studies (GWAS) to identify genetic variants associated with AS. The analysis highlights key loci, such as HLA-B27 and non-HLA genes, which are implicated in disease susceptibility. Furthermore, the review explores the potential mechanisms by which these genetic factors contribute to the pathogenesis of AS, providing insights into new therapeutic targets. The growing understanding of AS genetics may lead to more personalized treatment strategies in the future.