Endometrial thickness its association in anovulation and Obesity in reproductive age

Author(s): N Hephzibah kirubamani

Introduction: Endometrial response depends on variation in oestrogen levels for proliferation and obesity plays an important role in endometrial proliferation Objective: To evaluate relationship with endometrial thickness in anovulation and BMI Materials and Methods: A prospective cross sectional study conducted at saveetha Medical college Obstetrics and Gynaecologic department. After ethical clearance and informed consent 78 women between 20- 40 years were recruited with more than 45 days cycle. Premature ovarian insuffi ciency and uterine abnormalities were excluded. Number of cycles per year noted and total serum testosterone, androstenedione and estradiol levels were measured. The endometrial echo values obtained by transvaginal ultrasonography with the body mass index of women to verify if there is higher prevalence of endometrial thickening in women with high body mass index All the subjects were classifi ed into two groups: Group A, endometrial thickness < 7 mm, Group B endometrial thickness ≥ 7mm Women were classifi ed as obese based on their BMI and waist Hip ratio Results: Average age in the study 28.9 +- 3.9, average anovulatory interval was 147 +- 12 days waist Hip ratio 0.82+- 0.06 SD and average endometrial thickness was 8.5+- 3.8 mm BMI 53.5% of women presented an index > 25 , BMI 26-29.9 in 25.73% and BMI >30 in17.6% BMI > 30 all women and 26-29 BMI 18% had endometrial thickness more than 7mm.There was a statistically signifi cant correlation between overweight and obese patients and increased endometrial thickness (p=0.05). Among group A and group B there is no signifi cant correlation either with number of cycles in a year, age, with serum testosterone or estradiol level. Conclusion: This study shows that there is an infl uence of obesity on endometrial thickness. There is a positive correlation between Endometrial thickness and BMI .