Abstract

Comparison of Adults and Children's Clinical Henoch-Schönlein Purpura Manifestations and Results

Author(s): Joung-Liang Lan

Background

Henoch- Schönlein purpura ( HSP) primarily affects children, but age at onset is allowed to be important in determining complaint inflexibility and outgrowth. This study compared the clinical and laboratory data from children and grown-ups with HSP.

Methods

This retrospective 5- time study enrolled 65 children and 22 adult HSP cases attending a medical center.

Results

Gross hematuria and lower- extremity edema were significantly further frequent in grown-ups( p<0.05). All the children developed renal involvement within 2 weeks, while 67 of the adult cases developed hematuria by the fifth week of complaint onset. Elevated white blood cell count and increased erythrocyte sedimentation rate were significantly more common in children( p<0.05). Grown-ups had a advanced frequence of renal involvement ( p<0.05), though this was also present in 14 children(21.54), 12 with insulated hematuria and proteinuria and two with nephrotic pattern. All the children maintained normal renal function. Twelve grown-ups had renal involvement(52.6), six with progression to renal insufficiency. Cases with abdominal pain at complaint onset had a significantly advanced probability of developing nephrotic pattern (p<0.05). Logistic retrogression revealed that age> 20 times, manly, bloody droppings, clinical course with relapse of purpuric rash, and patient rash for> 1 month were poor prognostic pointers for HSP nephritis( p<0.05).

Conclusions

HSP nephritis in grown-ups had a advanced threat of progression to renal insufficiency. More aggressive treatment and extended follow- up with repeated urinalysis for at least 6 weeks were frequently necessary, especially in aged cases.