Abstract

Clinical phenomenology and diagnostic usefulness of autoantibodies in juvenile-onset myositis

Author(s): Sarah L Tansley

Objects Juvenile myositis is a rare and miscellaneous complaint. Opinion is frequently delicate but early treatment is important in reducing the threat of associated morbidity and poor issues. Myositis specific autoantibodies have been described in both juvenile and adult cases with myositis and can be helpful in dividing cases into clinically homogenous groups. We aimed to explore the mileage of myositis specific autoantibodies as individual and prognostic biomarkers in cases with juvenileonset complaint. Methods Using radio- labelled immunoprecipitation and preliminarily validated elisas we examined the presence of myositis specific autoantibodies in 380 cases with juvenile- onset myositis in addition to, 318 cases with juvenile idiopathic arthritis, 21 cases with juvenile- onset SLE, 27 cases with muscular dystrophies, and 48 healthy children. Results An autoantibody was linked in 60 of juvenile- onset myositis cases. Myositis specific autoantibodies (49 cases) were simply set up in cases with myositis and with the exception of one case were mutually exclusive and not set up in confluence with another autoantibody. Autoantibody subtypes were associated with age at complaint onset, crucial clinical complaint features and treatment entered. Conclusions In juvenile cases the identification of a myositis specific autoantibody is largely suggestive of myositis. Autoantibodies can be linked in the maturity of affected children and give useful prognostic information. There's substantiation of a discriminational treatment approach and cases withanti-TIF1γ autoantibodies are significantly more likely to admit aggressive treatment with IV cyclophosphamide and/ or birth medicines, clear trends are also visible in other autoantibody groups.