A Short Note on Neural Circuit Changes in Neurological DisordersAuthor(s): Justin Twain
Healthy brain function relies heavily on neural circuits like synaptic plasticity and neural activity. An on-going process that has an impact on the activities of neurons is the ensuing dynamic remodelling of neural circuits. Disturbance of this fundamental cycle brings about infections. Because it is able to observe fine structural and functional cellular activation in living animals, advanced microscopic applications like two-photon laser scanning microscopy have recently been used to comprehend the changes that take place in the neural circuit during disease. The most recent research on the dynamic rewiring of postsynaptic dendritic spines and modulation of calcium transients in intact living brain neurons, with an emphasis on their potential roles in neurological disorders like Alzheimer's disease, stroke, and epilepsy, has been summarized in this review. Understanding the fine changes that happened in the mind during sickness is pivotal for future clinical mediation improvements.