Viral Gene Therapy Impact Factor
Loss of function
mutations and abnormal
gene expression are two key reasons which cause genetic disorders. Based on the technique used, three other sorts of
gene therapy are:
•
Gene augmentation therapy
•
Gene inhibition therapy
• Suicidal
gene therapy
Gene augmentation therapy:
The natural function of a
gene is lost due to some
mutations known as a loss of function mutations, consequently, normal functional protein can’t be translated.
In the
gene augmentation therapy, the mutant is replaced by the fully functional wild type
gene that translated a wild type protein again. The present technique is majorly used for monogenic disorders. Cystic fibrosis-like disorders can be treated using
gene augmentation therapy.
Gene inhibition therapy:
Overexpression of a
gene causes some life-threatening disease conditions like cancer. Change within the
methylation pattern or epigenetic profile of a specific
gene leads to the overexpression/underexpression of that specific gene.
In the
gene inhibition therapy, the overexpressed
gene is inhibited by using,
1. another
gene or DNA sequence
2. or by interfering with the activity of the product of that gene.
The present
gene therapy is that the most suitable option to treat genetic disease , communicable disease , and cancer. The overexpression of oncogenes can be lessened by using this method.
Suicidal
gene therapy:
In some sorts of diseases, it's very necessary to kill the cell, especially in cancer.
For those types of cells, some of the genes called suicidal genes are introduced to kill the cells. The
Gene produces a toxic product or protein that induces a strong
immune response against that cell that leads to cell death. Suicidal
gene therapy is specially designed to cure cancer.
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