Journal of Biochemistry Research

Top Open Access Glycomics Journals

Glycomics is a subset of the glycobiology field which aims to identify the structure and function of the complete set of glycans (glycomes) produced in a given cell or organism and to identify all the genes that encode glycoproteins. The term "glycomics" currently describes studies designed to define the full repertoire of glycans produced by a cell or tissue under specified time , location, and environment conditions. "Glycoproteomics" describes this glycoma as it appears on the proteome of the cells. Glycoproteomics determines which sites are glycosylated on each glycoprotein in a cell and ideally includes identification and quantitation of each glycan structure on the heterogeneous glycoforms in the cell at each site. This complexity renders both exciting and daunting glycomics and glycoproteomics. Talking about the general analysis strategies for glycomics, glycoproteins / proteoglycans or glycolipids, enzymatic or chemical methods can release free glycans. Mass spectrometry (MS) can derivatize, separate, or further analyze the glycans. Or after derivatisation, the glycan can also be analyzed directly by MS. For analysis the glycan microarrays are generated in the shotgun glycomics for functional studies. The structural analysis of glycoproteins is a challenging effort and is under constantly increasing demand, but only a very limited number of laboratories have the expertise necessary to fulfill this task 

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