ISSN: 2041-6792

Clinical Investigation

Top Journals In Cytogenetics

Cytogenetics refers to both the study of the structure of chromosome material and the study of diseases caused by structural and numerical abnormalities of chromosomes. It includes the routine analysis of G-banded chromosomes, other cytogenetic banding techniques, and molecular cytogenetics such as fluorescent in situ hybridization (FISH) and comparative genomic hybridization (CGH). In human medicine, cytogenetics has played an important role in the diagnosis and clinical management of lymphomas, leukemias, and various solid tumors. Breakthroughs in karyotype analysis have overcome the impediments presented by the complexity of the canine karyotype (2 N=78) in identifying rearranged chromosomes. Both numerical and structural chromosome abnormalities have been identified in canine soft tissue sarcomas. Although many of the cytogenetic studies of animal tumors have been small case series, the advent and development of microarrays for canine CGH analysis will facilitate future studies. In a small study of canine leukemia, cytogenetic abnormalities did not correlate with survival. Similarly, a small study of feline leukemia found no relationship between cytogenetic abnormalities and prognosis. In a study of the cytogenetics of canine lymphoma, dogs with tumors having trisomy 13 had a significantly longer median survival time compared to dogs with tumors having other chromosomal aberrations. Further studies are needed to determine the prognostic importance of chromosomal aberrations in veterinary oncology.    

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