Stem Cell Research and Regenerative Medicine

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 Mesenchymal stem cells (MSCs) square measure strong adult stem cells that have self-renewal capability and differentiation efficiency into many specialised cell sorts a minimum of in mesoblast origin. The MSCs were 1st isolated from placental mammal bone marrow by Friedenstein and their colleagues in 1976. They ascertained that the isolated cells may adhere to plastic culture dishes and had feature as spindle-shape cells like formative cell. Moreover, the adherent cells incontestible as clonogenic feature or being density kind that was outlined as colony-forming unit fibroblasts (CFU-F) characteristic. Over the past years, ensuant studies found that these cells may differentiate into mesodermallineage cells like formative cell, adipocytes and chondrocytes in vitro. though there square measure many terms for outlining these cells like marrow stromal cells, strong stromal cells, bone marrow stromal stem cells and multi-potent adult primogenitor cells, mesenchymal stem cells square measure wide mentioned by many studies supported their differentiation potential toward mesoblastic tissues or all connective tissues like fatty , bone and gristle. Currently, MSCs are referred to as promising tool for therapeutic purpose in clinic supported their many benefits as well as selfrenewal, intensive in vitro enlargement, immunomodulation property, engraftment capability, multi-lineages differentiation potential as well as few moral considerations as compared to embryonic stem cells. Moreover, increasing evidences are shown that MSCs is isolated from numerous cell sorts as well as animal tissue, dental pulp, peripheral blood, placenta and epithelial duct. Wilairat Leeanansaksiri, Mesenchymal Stem Cells: Current Clinical Applications and Therapeutic Potential in Liver Diseases

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