Journal of Labor and Childbirth

Sperm DNA Impact Factor

            The integrity of genetic material in sperm is very important for the successful fertilization and normal development of the embryo. Sperm DNA fragmentation is a term used to refer to abnormal genetic material in sperm, which in turn can cause male subfertility, IVF failure, and miscarriage. Mammalian seed DNA is the best known compact eukaryotic DNA which is six times denser than the solid mitotic chromosomes of somatic cells. For example, the nucleus of a rat seed is compressed to a volume that is approximately 20 times smaller than the nucleus of a liver cell. Sperm DNA damage is a major cause of sperm dysfunction. In addition, oxidative stress due to endogenous factors and various exogenous factors is a major cause of DNA damage and a leading cause of loss of integrity in the mitochondrial and nuclear genomes. Various treatment strategies can increase sperm DNA damage, e.g. B. Antioxidants and oral varicocelectomy. Oxidative stress leads to membrane function and DNA damage in sperm by producing excess reactive oxygen species. This phenomenon can help to understand the causes of infertility in patients with varicoceles with normal sperm parameters.

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