Sepsis Scientific Journals

 Sepsis, as a manifestation of several endemic and epidemic diseases, has had a profound impact on the history of humankind. One of the most illustrative examples is the plague epidemic, which, in its septicemic form, decimated a third of the European population in the 14th century. Today, sepsis remains a major cause of morbidity and mortality worldwide. The actual number of cases is unknown, as there is limited information from developing countries. In a recent multicenter study performed in Brazil, one-third of intensive care beds were occupied by septic patients, with a mortality rate of 55.7%. Additionally, the rise in antimicrobial resistance and nosocomial sepsis has been a matter of concern, with studies suggesting that by the year 2050, 10 million people will have died annually worldwide due to healthcare-associated infections.