ISSN: 2041-6792

Clinical Investigation

Scholarly Peer Review Proteomics Journals

Proteomics is a rapidly growing field of molecular biology that is concerned with the systematic, high-throughput approach to protein expression analysis of a cell or an organism. Typical results of proteomics studies are inventories of the protein content of differentially expressed proteins across multiple conditions. The cell responds to internal and external changes by regulating the activity and level of its proteins; therefore changes in the proteome (a collection of all the proteins coded in our genes) provide a snapshot of the cell in action. Proteomics enables the understanding the structure, function and interactions of the entire protein content in a specific organism. The term “protein” was initially introduced in 1938 by the Swedish chemist Jöns Jakob Berzelius, an accomplished experimenter in the field of electrochemistry. He wanted to describe a particular class of macromolecules that are plentiful in living organisms and made up of linear chains of amino acids. The terms “proteome” and “proteomics” were coined in the early 1990s by Marc Wilkins, a student at Australia's Macquarie University, in order to mirror the terms “genomics” and “genome”, which represent the entire collection of genes in an organism. In many ways, proteomics runs parallel to genomics. The starting point for genomics is a gene in order to make inferences about its products (i.e. proteins), whereas proteomics begins with the functionally modified protein and works back to the gene responsible for its production.    

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