ISSN: 2041-6792

Clinical Investigation

Scholarly Journals In Cell Migration

Synthetic extracellular matrices produces a structure in which cells can be revealed to defined biological and physical cues, however no method exists today to operate single cells within these matrices to understand fundamental theory of cell migration and explain conditions that inhibit or support cell movement. Here, we present a strategy for operating individual mammalian stem cells in defined synthetic hydrogels through selective optical activation of Rac. A visible laser was applied to convey directional migration of mammalian stem cells in poly(ethylene glycol), PEG, based hydrogel networks consolidated with an adhesion peptide ligand, Tyr-Arg-Gly-Asp-Ser (YRGDS). Mesenchymal stem cells (MSCs) were transferred with a genetically encoded photoactivatable Rac1 (PA-Rac). Rac is a subfamily of Rho GTPases that plays an important role in cell migration by stimulating actin polymerization.

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