Scholarly Journals Developing Drugs
Drug development process involves rigorous testing and optimization of selected compounds to spot the drug that's most effective. This testing is completed in
cells (in vitro) and in animals (in vivo) to review the metabolism and to supply a product that's safe and has passed all regulatory requirements.
Drugs failure in clinical practice is due in large part to 2 main reasons. the primary reason is that if they are doing not work properly and therefore the second reason is, if they're not safe. The 2 most vital issues to deal with in drug invention processes are; to spot a target and validation. This might be a protein receptor that is related to a disease condition, for this reason, it's important to understand how the disease occurs at the molecular, cellular and genetic levels. Once the target is identified, then subsequent step is how the target plays a task in the disease process. this is often administered by testing the target against different known and new compounds to understand either one or several compounds that interact with the target and show either to neutralize or hamper the disease process.
Stages of Drug Development
➢Drug Invention
➢Product Characterization
➢Formulation& development
➢Pharmacokinetics And Drug Disposition
➢Preclinical
Toxicology Testing And IND Application
➢Bioanalytical Testing
➢Clinical Trials
➢Regulatory review
➢Marketing the product or drug
➢Post-marketing monitoring (phase-IV) trials.
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