Reperfusion

  Reperfusion obviously influences the release of TnT in AMI patients (K10, M3). In AMI patients with early reperfusion, TnT appears in serum significantly earlier and peak values are observed significantly earlier as well. In patients who undergo thrombolytic treatment TnT concentration changes on the first day vary highly (see Fig. 5). The appearance of TnT in serum on day 1 after the onset of AMI depends strongly on reperfusion and on the duration of ischemia until reperfusion occurs (K10). AMI reperfusion obviously leads to a “washout” of the free cytosolic TnT pool, resulting in a rapid increase in TnT. By contrast, the kinetics of TnT release after the first 38 hours after AMI is unaffected by reperfusion.