ISSN: 2044-9038 (Print) 2044-9046 (Electronic)

Clinical Practice

Premature Failure Ovarian

Premature ovarian failure is a condition in women where the ovaries stop producing eggs unusually before the age of 40. this is often different from the menopause, which generally occurs round the age of fifty. The cessation of menstrual periods is that the commonest symptom that raises concern. this will be related to other menopausal-like symptoms like hot flushes, sweats and mood changes. It’s relatively rare, occurring in one in 1,000 women under the age of 30 and one in 100 women under the age of 40. Diagnosis is made on the idea of a careful clinical assessment, blood tests to seem at hormone levels, antibodies and genetic tests, all of which may be done as an outpatient. An ultrasound scan of the ovaries is usually performed to seem at the structure of the ovaries and therefore the uterus. Elicitation of an in depth history would help in suggesting the diagnosis of POF by excluding other common causes of amenorrhoea. These include pregnancy, hypothalamic amenorrhoea (caused by anorexia nervosa, exercise, stress and weight loss), hyperprolactinaemia (symptoms include headaches and galactorrhoea) and polycystic ovary syndrome (symptoms include hirsutism and acne). A history of chemotherapy, radiotherapy or pelvic surgery within the past is clearly relevant. A history of obstetric catastrophe, severe bleeding, dilatation and curettage or infection indicates a uterine cause (Asherman syndrome) and history pertinent to autoimmune disorders, including hypothyroidism or adrenal insufficiency, should also be elicited.

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