Pharmacology Online Journals

Pharmacology is that the study of how a drugs works, how the body responds thereto , and therefore the changes that occur over time. Non-clinical pharmacological studies allow scientists to match a medicine’s beneficial effects with its negative (toxic) effects. This comparison is vital in order that a radical benefit-risk analysis are often made before proceeding to check the drugs in clinical (human) studies. If the drugs does proceed to the clinical phase, data gathered during non-clinical pharmacology and toxicology studies help to work out the dosage of drugs given to volunteers within the first clinical studies (first-in-human). The primary objective of pharmacodynamic studies is to collect information on how the drugs affects the body (for instance, what receptors it activates). This allows scientists to assess the efficacy of the drugs – that's , whether or not the drugs has the specified effect on the target, and if so, how strong that effect is. It also allows a far better understanding of the connection between the concentration of the drugs within the body and therefore the strength of its effect.Pharmacodynamic studies are crucial for the safety assessment of a medicine. They identify any undesirable effects that the drugs has and investigate the range of doses at which the specified effect of the drugs on the body occurs (therapeutic dose range).

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