Stem Cell Research and Regenerative Medicine

Peer-review Journals In Cell Culture

Primary culture refers to the stage of cultivation after the cells are isolated from the tissue and proliferated under appropriate conditions until they occupy all the available substratum (i.e., reach confluence). The cells must be subcultured (i.e. passed) at this stage by transferring them to a new vessel with a fresh growth medium in order to provide more room for continuous growth. Cell culture is one of the main tools used in cellular and molecular biology, providing excellent modeling systems for the study of normal cell physiology and biochemistry (e.g., metabolic studies, aging), the cell effects of drugs and toxic compounds, and mutagenesis and carcinogenesis. It is also used in the screening and development of drugs, and in the production of biological compounds ( e.g., vaccines, therapeutic proteins) on a large scale. The main advantage of using cell culture for any of these applications is the consistency and reproducibility of the results obtainable from the use of a batch of clonal cells.

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