Stem Cell Research and Regenerative Medicine

Peer Reviewed Journals In Novel Bone Marrow

Studies have shown global and regional improvements in function after injection of Bone Marrow Stem Cell (BMSC) into viable, peri-infarct areas of chronically ischemic myocardium. It has been shown that bone marrow-derived CD34 + and CD 133 + cells which exhibit endothelial phenotypes contribute to neovascularisation. At the time of Coronary Artery Bypass Graft (CABG), intramyocardial injection of purified CD133 + BMSC which was involved in their direct application into the diseased myocardium. Bone marrow or mobilized progenitor cells in the peripheral blood may play a role in the ischemic myocardium revascularisation. These features in patients with Chronic Myocardial Infarction (CMI) may explain the improved Left Ventricular Ejection Fraction (LVEF).

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