Osmopressor Response Impact Factor

In patients with chronic autonomic failure (AF), drinking water increases mean blood pressure (MBP). This is an “osmopressor” response mediated by osmoreceptors on afferent neurons with their cell bodies in the dorsal root ganglia (DRG). Osmoreceptor activation triggers sympathetic excitation via a spinal reflex. Familial dysautonomia (FD) is a genetic disease that affects the development of primary afferent neurons with cell bodies in the DRG, but leaves efferent sympathetic neurons functionally intact. Our objective was to investigate whether this osmopressor response was present in FD. Beat-to-beat BP and RR intervals were recorded for 10 minutes prior and for 30 minutes after ingesting 500ml of water while supine. Thirty minutes after the water, MBP was significantly higher in the patients with AF than in those with FD (Δ15±5mmHg and Δ0±4mmHg respectively, P 

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