ISSN: 2044-9038 (Print) 2044-9046 (Electronic)

Clinical Practice

Open Access Metabolomics Journals

 Metabolomics is that the scientific study of chemical processes involving metabolites, the tiny molecule substrates, intermediates and products of metabolism. Specifically, metabolomics is that the "systematic study of the unique chemical fingerprints that specific cellular processes leave behind", the study of their small-molecule metabolite profiles. The metabolome represents the entire set of metabolites during a biological cell, tissue, organ or organism, which are the top products of cellular processes. mRNA organic phenomenon data and proteomic analyses reveal the set of gene products being produced within the cell, data that represents one aspect of cellular function. Conversely, metabolic profiling can give an instant snapshot of the physiology of that cell, and thus, metabolomics provides an immediate "functional readout of the physiological state" of an organism. One of the challenges of systems biology and genomics is to integrate genomics, transcriptomic, proteomic, and metabolomic information to supply a far better understanding of cellular biology. The concept that individuals may need a "metabolic profile" that would be reflected within the makeup of their biological fluids was introduced by Williams within the late 1940s, who used chromatography to suggest characteristic metabolic patterns in urine and saliva were related to diseases like schizophrenia. However, it had been only through technological advancements within the 1960s and 1970s that it became feasible to quantitatively (as against qualitatively) measure metabolic profiles. The term "metabolic profile" was introduced by Horning, et al. in 1971 after they demonstrated that gas chromatography-mass spectrometry (GC-MS) might be wont to measure compounds present in human urine and tissue extracts. The Horning group, along side that of Pauling and Arthur B. Robinson led the event of GC-MS methods to watch the metabolites present in urine through the 1970s.  

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