ISSN: 2041-6792

Clinical Investigation

Open Access Journals In Lipid Metabolism

 Lipid metabolism starts in the intestine, where pancreatic lipases break down the ingested triglycerides into smaller chain fatty acids and eventually into monoglyceride molecules, enzymes that break down fats after bile salts emulsify them. When food reaches the small intestine in the form of chyme, the intestinal mucosa releases a digestive hormone, called cholecystokinin (CCK). CCK induces pancreatic lipase release from the pancreas and induces gallbladder contraction to expel accumulated bile salts into the intestine. CCK travels to the brain too, where it can act as a suppressant of hunger. The pancreatic lipases and bile salts together break down triglycerides into free fatty acids. These fatty acids can be transferred across the gut membrane. When they cross the membrane, however, they are recombined to form triglyceride molecules once again. Such triglycerides are packed within the intestinal cells in phospholipid vesicles called chylomicrons along with cholesterol molecules.  

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