MTOR Top Open Access Journals
Mechanistic target of rapamycin (mTOR) may be a protein kinase regulating cell growth, survival, metabolism, and immunity. mTOR is typically assembled into several complexes like mTOR complex 1/2 (mTORC1/2). In cooperation with raptor, rictor, LST8, and mSin1, key components in mTORC1 or mTORC2, mTOR catalyzes the phosphorylation of multiple targets like ribosomal protein S6 kinase β-1 (S6K1), eukaryotic translation initiation factor 4E binding protein 1 (4E-BP1), Akt, protein kinase C (PKC), and type-I insulin-like protein receptor (IGF-IR), thereby regulating protein synthesis, nutrients metabolism, protein signaling, cell growth, and migration. Activation of mTOR promotes tumour growth and metastasis. Many mTOR inhibitors are developed to treat cancer. While a number of the mTOR inhibitors are
approved to treat human cancer, more mTOR inhibitors are being evaluated in clinical trials. Here, we update recent advances in exploring mTOR signaling and therefore the development of mTOR inhibitors for
cancer therapy. additionally , we discuss the mechanisms underlying the resistance to mTOR inhibitors in
cancer cells
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