Mitochondrial Permeability

Mitochondrial transition pore permeability is a transmembrane protein that resides within the inner membrane of the mitochondria. This large protein pore normally closed opens when stimulated by Ca2 + accumulation of the mitochondrial matrix, adenine nucleotide depletion, increased phosphate concentration or oxidative stress. Under a number of settings, mitochondrial transfer pore permeability is one of the main causes of cell death. For example, it 's important in excitotoxicity in neuronal cell death, where glutamate receptor overactivation causes excessive calcium entry into the cell.Also, mitochondrial transition pore permeability appears to play a key role in ischemia-induced damage, as occurs in a heart attack and stroke. Mitochondria, found within the cytoplasm of eukaryotic cells, is important for normal cell function.

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