Journal Of Atherosclerosis

 When plaque  clogs your arteries, that’s called atherosclerosis. These deposits are made from cholesterol, fatty substances, cellular waste products, calcium and fibrin (a clotting material within the blood).As plaque builds up, the wall of the vessel thickens. This narrows the channel within the artery, which reduces blood flow. That, in turn, lessens the quantity of oxygen and other nutrients reaching the body. Where plaque develops, and therefore the sort of artery affected, varies with everyone . Plaque may partially or totally block blood flow through large- or medium-sized arteries within the heart, brain, pelvis, legs, arms or kidneys. this will precipitate various conditions, including:Coronary heart condition (plaque in arteries in or resulting in the heart),Angina (chest pain from reduced blood flow to the guts muscle),Carotid artery disease (plaque in neck arteries supplying blood to the brain),Peripheral artery disease, or PAD (plaque in arteries of the extremities, especially the legs),Chronic renal disorder . Plaque itself can pose a risk. a bit of plaque can break off and be carried by the bloodstream until it gets stuck. And plaque that narrows an artery also allows for the likelihood that a grume (thrombus) may adhere to the blood vessel’s inner wall.If either case, the artery are often blocked, isolating blood flow.If the blocked artery supplies the guts or brain, a attack or stroke occurs. If an artery supplying oxygen to the extremities (often the legs) is blocked, gangrene, or tissue death, may result .  

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