Human Fibroblasts

                                  The depressant effects of local anesthetics on multiplication of culture cells have been demonstrated in human fibroblasts, human endothelial cells, human keratinocytes, type II pneumocytes, lung fibroblasts, and corneal epithelial cells. The adverse effects of lidocaine and other local anesthetics on wound healing remain controversial. This effect may be explained by changes in the stability of the cellular membrane and of sodium and calcium conductance. Although some studies have shown that wound healing was impaired by local anesthetic, others have not been able to verify deleterious effects. Observational studies have suggested that subconjunctival local anesthetic may be associated with an increased risk of blab failure or leakage in trabeculectomy, but there is no definite evidence to support this hypothesis.  

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