Stem Cell Research and Regenerative Medicine

High Impact Journals In Tissue Transplantation

 Human cells and tissues for transplantation can save lives or restore essential functions a corneal graft can restore sight in corneal blindness; the transplantation of haematopoietic stem cells can cure congenital or acquired diseases including some leukaemias (haematopoietic stem cells are often collected from living donors, either as bone marrow or from peripheral blood. Additionally, they'll be collected as cord blood drawn from the placenta during or after delivery.) See further information on Haematopoeitic Stem Cells the transplantation of a person's heart valve often constitutes the simplest replacement situation and recipient patients don't require future anti-coagulation therapy. Tissue or cell transplantation has been an extremely valuable technique for studying developmental potential of certain cell population, dissecting cell-environment interaction relationship, identifying stem cells, and many other applications. One key technical requirement for performing transplantation assay is that the capability of distinguishing the transplanted donor cells from the endogenous host cells, and tracing the donor cells over time. Zebrafish has emerged as a superb model organism for performing transplantation assay, because of the transparency of embryos during development and even certain adults. Using transgenic techniques and fast-evolving imaging technology, fluorescence labeled donor cells are often easily identified and studied in vivo. In this chapter, we'll first discuss the rationale of various sorts of zebrafish transplantation in both embryos and adults, then specialise in detailed methods of three types of transplantation: blastula/gastrula transplantation for mosaic analysis, somatic cell transplantation, and tumor transplantation.  

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