Stem Cell Research and Regenerative Medicine

Germline Stem Cells Open Access Journals

 Germline stem cells (GSCs) may generate haploid gametes, sperms, or oocytes that transfer genetic data from one generation to another. Because Germline stem cells can be easily detected, and gene functions in Drosophila and C. elegans can be easily manipulated, their niches were among the first to be functionally and anatomically characterized. In these processes, genetic and cell biology experiments have also demonstrated that stem cell activity is regulated by niche extracellular signals and intrinsic genetic programs within stem cells. Recently also significant progress has been made in locating Germline stem cells in the mouse testis. Germline stem cells share many common mechanisms in all organisms, although not necessarily molecules, to ensure germline survival.    

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