ISSN: 1755-5310 (Electronic)1755-5302 (Print)

Interventional Cardiology

Erythroderma Impact Factor

 Erythroderma is rare. It can arise at any age and in people of all races. It is about 3 times more common in males than in females. Most have a pre-existing skin disease or a systemic condition Erythrodermic atopic dermatitis most often affects children and young adults, but other forms of erythroderma are more common in middle-aged and elderly people. The most common skin conditions to cause erythroderma are: Drug eruption — with numerous diverse drugs implicated (list of drugs) Dermatitis especially atopic dermatitis Psoriasis, especially after the withdrawal of systemic steroids or other treatment Pityriasis rubra pilaris Other skin diseases that less frequently cause erythroderma may include: Other forms of dermatitis: contact dermatitis (allergic or irritant), stasis dermatitis (venous eczema) and in babies, seborrhoeic dermatitis or staphylococcal scalded skin syndrome Blistering diseases including pemphigus and bullous pemphigoid Sezary syndrome (the erythrodermic form of cutaneous T-cell lymphoma) Several very rare congenital ichthyotic conditions. Erythroderma may also be a symptom or sign of systemic disease. These may include: Haematological malignancies, such as lymphoma and leukaemia Internal malignancies, such as carcinoma of rectum, lung, fallopian tubes, colon, prostate (paraneoplastic erythroderma) Graft-versus-host disease HIV infection. It is not known why some skin diseases in some people progress to erythroderma. The pathogenesis is complicated, involving keratinocytes and lymphocytes, and their interaction with adhesion molecules and cytokines. The result is a dramatic increase in turnover of epidermal cells.

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