Journal of Biochemistry Research

Dyspepsia Articles

 Dyspepsia is a common term used for the abdominal symptoms of a heterogeneous population. This review focuses on Functional dyspepsia (FD). FD and its subgroups, postprandial distress syndrome (PDS) and epigastric pain syndrome (EPS) were defined in the Rome III criteria of 2006. FD is a very common condition with a high prevalence worldwide which adversely affects patients ' quality of life. For the last two decades the pathophysiology of FD has been under study. Multiple mechanisms are likely to be involved, such as abnormal gastric emptying, visceral hypersensitivity, impaired stomach accommodation and central nervous system factors. There are several tests available to assess different physiological functions that may be involved in FD pathogenesis, some of which may be used in clinical practice, helping to explain the symptoms that underline the concerns of patients. However, experience of using prokinetics, tricyclic antidepressants, selective serotonin-reuptake inhibitors (SSRIs), proton-pump inhibitors (PPIs) and other alternative therapies have been acquired, the possibilities of pharmacological therapy for FD are still restricted. The various combinations of alterations in gastrointestinal physiological and central nervous system functions result in FD being very heterogeneous in nature.  

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