Cytokine Transforming
In the course of last decade, it has known that the mammalian
immune system is able to perceive and partly suppress nascent tumors. Human T
cells specific to oncogenes and onco-fetal antigens are present in human
cancer patients and their tumors. At the same time, molecular links between
tumor progressions have been uncovered and tumor-associated inflammation, producing an explanation for the long perceived epidemiological link between
cancer and inflammation. The précis of these findings recommends a new interpretation of
tumor immunity. It materializes that or antigen-specific T-cell expansion or antigen recognition at huge is not as enormously impaired in
tumor patients as the correct polarization, the effector function and the survival of tumor-infiltrating T cells. This review will focus on pro-inflammatory cytokines likely to contribute to the deregulation of tumor-specific
immunity and its consequences.
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