Stem Cell Research and Regenerative Medicine

Cellular Stress Innovations

Cells can answer stress in various ways starting from the activation of survival pathways to the initiation of necrobiosis that eventually eliminates damaged cells. Whether cells mount a protective destructive stress response depends to an outsized extent on the character and duration of the strain also because the cell type. Also, there's often the interplay between these responses that ultimately determines the fate of the stressed cell. The mechanism by which a cell dies (i.e., apoptosis, necrosis, pyroptosis, or autophagic cell death) depends on various exogenous factors also because the cell's ability to handle the strain to which it's exposed. The implications of cellular stress responses to human physiology and diseases are manifold and can be discussed during this review within the context of some major world health issues like diabetes, paralysis agitans, myocardial infarct , and cancer. cells answer stress during a sort of ways starting from activation of pathways that promote survival to eliciting programmed necrobiosis that eliminates damaged cells. The cell’s initial response to a stressful stimulus is geared towards helping the cell to defend against and get over the insult. However, if the noxious stimulus is unresolved, then cells activate death signaling pathways. the very fact that the cell’s survival critically depends on the power to mount an appropriate response towards environmental or intracellular stress stimuli can explain why this reaction is very conserved in evolution.    

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