Cell Aging Journals
Cellular ageing is generally defined as the progressive decline in the resistance to
stress and other cellular damages, causing a gradual loss of cellular functions and resulting eventually in cell death. The mechanisms of ageing, whether replicative or chronological, are ill-defined. Research using different genetic
model organisms led to the identification of about twenty genes that can prolong the lifespan of an organism (1-6). Remarkably, studies using Caenorhabditis elegans, mouse, and yeast models revealed the existence of common pathways controlling ageing in these organisms. For instance, studies in S. cerevisiae resulted in the identification of two cellular pathways involved in the control of chronological ageing. One of them is the RAS/cAMP/PKA cascade. The other one, is based on the discovery of SCH9 gene. These pathways are involved in the regulation of the cell’s defence response against free radicals, and other reactive oxygen
molecules that accumulate in the cell with time and damage
macromolecules such as DNA, RNA and proteins. Our main objective is to identify novel genes involved in the mechanisms of chronological ageing. These genes will be studied in terms of their interaction with other cellular components and their role in the pathways in which they act.
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