ISSN: 2044-9038 (Print) 2044-9046 (Electronic)

Clinical Practice

Anti-inflammatory Drug Journals

Nonsteroidal anti-inflammatory drugs are members of a drug class that reduces pain, decreases fever, prevents blood clots, and in higher doses, decreases inflammation. Side effects depend upon the precise drug but largely include an increased risk of gastrointestinal ulcers and bleeds, attack , and renal disorder .NSAIDs work by inhibiting the activity of cyclooxygenase enzymes (COX-1 or COX-2). In cells, these enzymes are involved within the synthesis of key biological mediators, namely prostaglandins, which are involved in inflammation, and thromboxanes, which are involved in blood coagulation .There are two sorts of NSAIDs available: non-selective and COX-2 selective.[5] Most NSAIDs are non-selective and inhibit the activity of both COX-1 and COX-2. These NSAIDs, while reducing inflammation, also inhibit platelet aggregation (especially aspirin) and increase the danger of gastrointestinal ulcers/bleeds. COX-2 selective inhibitors have less gastrointestinal side effects but promote thrombosis and substantially increase the danger of attack . As a result, COX-2 selective inhibitors are generally contraindicated thanks to the high risk of undiagnosed vascular disease. These differential effects are thanks to the various roles and tissue localisations of every COX isoenzyme. By inhibiting physiological COX activity, all NSAIDs increase the danger of kidney diseaseand through a related mechanism, attack . additionally , NSAIDS can blunt the assembly of erythropoietin leading to anaemia, since haemoglobin needs this hormone to be produced. Prolonged use is dangerous and case studies have shown the health risk with celecoxib.    

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