The role of respiratory microbiota in the pathogenesis of chronic respiratory diseases

Author(s): Haddad Pierre

A large number of bacteria, including Firmicutes, Actinobacteria and Bacteroidetes, colonize the respiratory mucosal surfaces of healthy individuals. They interact and coexist with the local mucosal immune system of the human respiratory tract, maintaining immune stability and respiratory system balance. With chronic respiratory diseases, the microbial population in the respiratory tract changes and the proportion of proteobacteria increases in asthmatic patients. The abundance of the microbial population in patients with chronic obstructive pulmonary disease (COPD) decreased and, conversely, the proportion of Firmicutes and Proteobacteria increased. The diversity of the respiratory microbiota in cystic fibrosis (CF) patients is reduced, while pathogenic and conditioned bacteria proliferate in large numbers.