T Regulatory Lymphocytes and Endothelial Function in Pediatric Obstructive Sleep Apnea.

Author(s): Rovert Jam

Obstructive upset (OSA) might be a low-grade disease affecting the cardiovascular and metabolic systems. Increasing OSA severity reduces T-regulatory lymphocytes in OSA children. Since modulate endothelial activation, and attenuate insulin resistance, we hypothesized that are associated with endothelial and metabolic dysfunction in pediatric OSA. 50 consecutively recruited children (ages 4.8–12 years) underwent overnight polysomnography and fasting homeostatic model (HOMA) of insulin resistance was assessed. Percentage of using flow cytometry, and endothelial function, expressed because the time to peak occlusive hyperemia (Tmax), were examined. During a subgroup of children (n=21), in vitro suppression tests were performed. Circulating Tregs weren’t significantly associated with either BMI z score or HOMA. However, a serious inverse correlation between percentage of Tregs and Tmax emerged (p<0.0001, r=−0.56). a giant correlation between suppression and also the sleep pressure score (SPS), a surrogate measure of sleep fragmentation emerged (p=0.02, r=−0.51) emerged, but wasn’t present with AHI. Endothelial function, but not insulin resistance, in OSA children is strongly associated with circulating Tregs and their suppressive function, and appears to correlate with sleep fragmentation. Thus, alterations in lymphocyte lymphocytes may contribute to cardiovascular morbidity in pediatric OSA.