Stimulation of Fracture Healing in a Murine Osteoporosis Model by Pasty Bone Cement Functionalized with Brain-Derived Neurotrophic Factor

Author(s): Katrin Susanne Lips

Fragile bone with altered microarchitecture and increased fracture incidence is characteristic for osteoporosis. Failure of implant fixation and low osteoinductivity raises the quest for new supporting bone substitute materials. Brain-Derived Neurotrophic Factor(BDNF) is a growth factor that enhances in vitro the vitality of bone forming osteoblasts but not bone resorption by osteoclasts. Here, we asked whether integration of BDNF into Pasty Calcium Phosphate Cement (pCPC) via coating of Mesoporous Bioglas Particles (MBG) is able to stimulate fracture healing in a murine osteoporosis model.