Renal Osteodystrophy Treatment and CauseAuthor(s): Edward Martin*
The term "renal osteodystrophy" is used to describe the wide variety of skeletal deformities that affect people with chronic kidney disease. The two primary disorders are adynamic bone disease, which has low bone turnover and low levels of circulating PTH, and osteoitis fibrosa, which is characterised by fast bone turnover, enhanced osteoclastic and osteoblastic activity, and high levels of circulating parathyroid hormone (PTH).
Renal osteodystrophy is primarily caused by the retention of phosphorus, decreased blood levels of calcitriol, lower levels of serum ionised calcium, decreased numbers of vitamin D receptors and calcium sensors in the parathyroid gland, and skeletal resistance to PTH's calcemic activity. The current strategy for treating renal osteodystrophy will be discussed in this review .