Abstract

Mitigating Cardiovascular Risk from the Isosorbide Dinitrate-Sildenafil Interaction: A QbD-Optimized analytical method for Therapeutic Drug Monitoring Strategy

Author(s): Mohamed Momtaz

Public health, particularly for the elderly population, continues to be our foremost concern, with ongoing monitoring to ensure well-being. This emphasis stems from the understanding that functional health in advanced age arises from the accumulated impacts of diseases and natural physiological alterations associated with aging notably. Angina pectoris predominantly affects individuals aged 60 and above, highlighting the vulnerability of this demographic in terms of treatment options. Isosorbide dinitrate is an FDA-approved medication indicated for the prevention of angina pectoris caused by coronary artery disease. However, patients should be aware that this drug lacks the rapid onset required to halt an angina attack that is already underway, necessitating alternative interventions for acute episodes. By prioritizing preventive strategies and education, we aim to enhance quality of life and reduce health risks in older adults.