Abstract

Medicinal Perspective of Quinazolinone Derivatives as an Anticancer Agent

Author(s): Anushri Deulkar*

Cancer is a disease in which abnormal cells divide uncontrollably and destroy body tissue. Cancer is a leading cause of death worldwide, accounting for nearly 10 million deaths in 2020 or nearly one in six deaths. Although there are many anticancer medications available to treat cancer, their therapeutic efficacy is limited for a variety of reasons. Therefore, the discovery of novel cancer treatments is required. Quinazoline, Quinoxaline, Cinnoline, and Phthalazine are the four isomers of quinazoline that comprise up the class of bicyclic aromatic ring structures that have a benzene ring bonded to a two-nitrogen aromatic ring. A broad range of compounds known as quinolines have a variety of pharmacological actions. They have a variety of additional uses, including anti- histaminic, anti-cancer, anti-convulsant, anti-tubercular and anti-viral properties. Many FDA-approved anticancer drugs have their principal chemical structure as 4-aminoarylquinazoline. The purpose of this review is to present several aspects of medicinal chemistry, including drug design, the structure activity relationship and the mode of action of several distinct anticancer quinazoline derivatives. This review provides medicinal chemists with a comprehensive viewpoint to assist in the development of novel quinazolines as targeted chemotherapeutic agents.