Medicinal and Organic Natural Products Drug DiscoveryAuthor(s): Dr. Priyanka Upmanyu
Since ancient times and in folklore, natural products have been used to treat a wide variety of ailments. A wide variety of bioactive secondary metabolites from terrestrial and marine sources were discovered using traditional natural product chemistry methods. Numerous of these natural products are currently being considered as drug candidates. The purpose of this brief overview is to draw attention to historically significant bioactive marine and terrestrial natural products, their use in folklore, and methods of dereplication to speed up the discovery process. Additionally, a discussion of how the chemistry of natural products has led to the discovery of numerous drug candidates; the future of natural product chemistry, the use of advanced hyphenated spectroscopic techniques to aid in their discovery, and finally the adoption of metabolomic profiling and dereplication strategies for the comprehensive study of natural product extracts will all be discussed.