Abstract

Impact of Recipient Polymorphisms in the KRAS Gene rs712 on the Overall Survival Rate of Hepatocellular Cancer Following Liver Transplantation

Author(s): Kan Gong

Hepatocellular carcinoma (HCC) is the most common primary malignancy of the liver and a leading cause of cancer-related mortality worldwide. Liver transplantation (LT) is a curative treatment option for patients with HCC, particularly those who meet Milan criteria. However, the overall survival (OS) rates following LT for HCC vary significantly between individuals, suggesting that genetic factors may influence patient outcomes. This article explores the potential impact of recipient polymorphisms in the KRAS gene, specifically the rs712 polymorphism, on the survival rate of HCC patients following liver transplantation. The role of genetic variability in treatment response and prognosis following LT is of growing interest, and this article provides an overview of recent research examining the KRAS gene’s role in HCC and liver transplantation outcomes.